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Deciphering neural waves

Research conducted by an international team of specialists including Polish researcher Ryszard Auksztulewicz, at the City University of Hong Kong, shows that in various species, including humans, it is possible to decode the content of auditory sensory memory, based on the activity of the lobe of the brain responsible for the sense of hearing. 

The study explains in very simple terms what auditory sensory memory is in general and how it works. Well, it is a component of working memory, that is, the one responsible for such basic processes as understanding language or reading. It is also a set of cycles responsible for short-term storage and processing of new information. Auditory memory is one of the many components of working memory, responsible for the short-term storage of auditory information. 

The study involved reading neural activity in humans and rats. Twenty-one participants with perfectly healthy hearing volunteered for the experiment. In addition to the human volunteers, 8 female rats, also with healthy hearing, were selected. Readings were taken from fully conscious experimental subjects and anesthetized rodents. Interestingly, in both species, regardless of the state of consciousness, the readings were very similar. In humans, readings were taken from the scalp using a special cap equipped with electrodes, (electroencephalography). In animals, on the other hand, the procedure was carried out under full anesthesia, and the data were obtained directly from the auditory cortex (electrocorticography).

The test was conducted in the same way on all participants. Streams of vowel clusters and sound pulses were played to them in a certain way. The length of the pauses, the frequency of the tones and the jitter value were randomly assigned to each trial, but were the same for all participants in a given test round. Each participant underwent 10 trials. During the study, the researchers posed two hypotheses. The first – the stimuli preceding a sound impulse can be deciphered not only on the basis of the neural activity evoked by those stimuli (auditory perception), but also on the basis of the neural activity evoked by the sound impulse itself (auditory memory). The second hypothesis, which was the subject of a separate study published in 2022, was that it is possible to decipher not only the content of memory, but also the prediction of subsequent sounds, based on neuronal activity.

The conclusion of this research has several aspects. Namely, memory and prediction of stimuli that occur in the near future can be recognized by neuronal activity, which occurs regardless of the state of consciousness. The prediction of sounds is dynamic and changes on the fly during stimulation. Future studies in rats and humans will allow scientists to expand their knowledge of how other types of memory and prediction processes can be recognized based on neuronal activity.

Bibliography:

  1. Cappotto D*, Auksztulewicz R*, Kang HJ, Poeppel D, Melloni L, Schnupp J (2021) Decoding the content of auditory sensory memory across species. Cereb Cortex 31(7), 3226-3236. 
  2. Cappotto D, Kang HJ, Li KY, Poeppel D, Melloni L, Schnupp JWH, Auksztulewicz R* (2022) Simultaneous Mnemonic and Predictive Representations in the Auditory Cortex. Curr Biol 32(11), 2548-2555.
prof. Ryszard Auksztulewicz
Professor and research group leader
Bio:

Neuroscientist specialising in the brain mechanisms of prediction, attention, and memory, currently working as a visiting professor and research group leader at the Free University Berlin. His research combines empirical methods of cognitive and systems neuroscience with computational modelling. His previous postdoctoral training includes research fellowships at University College London (with Prof. Karl Friston) and University of Oxford (Prof. Kia Nobre), and the Marie Skłodowska-Curie Global Fellowship at the City University of Hong Kong (Prof. Jan Schnupp) and the Max Planck Institute in Frankfurt (Prof. Lucia Melloni). Graduate of Adam Mickiewicz University (Poznań, Poland) and University of Amsterdam.

Written by:

Katarzyna Roczek

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